Localisation effects on the Vibron Shifts in Helium-Hydrogen Mixtures

The vibrational frequency of hydrogen molecules has been observed to increase strongly with He concentration in helium hydrogen fluid mixtures. This has been associated with He-H interactions, either directly through chemical bonding, or indirectly through increased local pressure. Here, we demonstrate that the increase in the Raman frequency of the hydrogen molecule vibron is due to the number of H$_2$ molecules participating in the mode. There is no chemical bonding between He and H$_2$, helium acts only to separate the molecules. The variety of possible environments for H$_2$ gives rise to many Raman active modes, which causes broadening the vibron band. As the Raman active modes tend to be the lower frequency vibrons, these effects work together to produce the majority of the shift seen in experiment. We used Density Functional Theory (DFT) methods in both solid and fluid phases to demonstrate this effect. DFT also reveals that the pressure in these H$_2$-He mixture is primarily due to quantum nuclear effects, again the weak chemical bonding makes it a secondary effect

Perceptions and experiences of laws and regulations governing access to opioids in South, Southeast, East and Central Asia: A systematic review, critical interpretative synthesis and development of a conceptual framework

© The Author(s) 2020. Background: Opioids are essential medicines. Despite international and national laws permitting availability, opioid access remains inadequate, particularly in South, Southeast, East and Central Asia. Aim: To review evidence of perceptions and experiences of regulatory enablers and barriers to opioid access in South, Southeast, East and Central Asia. Design: Systematic review of post-2000 research according to PRISMA guidelines. Data were subjected to critical interpretive synthesis. International, national and sub-national barriers were organised developing a conceptual framework of opioid availability. Data sources: PsycINFO, Medline, Embase, The Cochrane Library. CINAHL, Complete and ASSIA from 2000 until 20th May 2019. Results: 21/14097 studies included: quantitative n = 15, qualitative n = 3 and mixed-methods n = 3. Four barrier/enabler themes were developed: Legal, regulatory, socio-political; lack of laws explicitly enabling opioid access, restrictive international controls and clinician prescribing concerns. Opioid availability; limited availability, poor policymaker and clinician education regarding opioid benefits, poor continuity of supply. Opioid Accessibility; medicine costs, distance to prescribing centres. Prescribing; extensive bureaucratic barriers, lack of human resources for prescribing. We present a novel framework of a self-perpetuating model of inadequate opioid provision. The Single Convention on Narcotics provides the context of restrictive laws and negative attitudes amongst policymakers. A consequent lack of prescribers and clinicians’ negative attitudes at sub-national levels, results in inadequate access to and use of opioids. Data of inadequate consumption informs annual requirement estimates used by the International Narcotics Control Board to determine future opioid availability. Conclusions: Regulatory and socio-political actions unintentionally limit opioid access. International and national laws explicitly enabling opioid access are required, to assuage concerns, promote training and appropriate prescribing

Repeated downsweep vocalizations of the Araguaian river dolphin, Inia araguaiaensis

Funding was provided by the Swarosvki Foundation and World Wide Fund for Nature Brazil.Araguaian botos (Inia araguaiaensis) are known to produce pulsed as well as tonal sounds. This study documents the first evidence for repetitive sequences of downsweep whistles in botos that appear to be shared between individuals, and the context of their occurrence is investigated. Boat surveys were conducted along the Tocantins River located in the Eastern Amazon over a period of 42 days between 2012 and 2018. Eighty-two groups of Araguaian botos were observed, and 43 h of sound recordings were acquired. 632 downsweep whistles were recorded in 10 encounters. Four of these encounters contained downsweep bouts (21 bouts with ≥2 whistles) with short inter-call intervals (bout criterion 50 s) and up to 161 whistles. A statistical relationship was not found between downsweep occurrence and any of the contextual parameters that were investigated, including socializing, travelling, feeding, group size, presence of calves, and socio-sexual displays. The rarity of these signals makes them unlikely candidates for individual or group identification. It is more likely that they are associated with very specific contexts, such as nursing or mating, both of which were rarely observed in this study. Further studies are required to investigate context specificity and elucidate the function of these signals.PostprintPeer reviewe

Playful mapping in the digital age:The Playful Mapping Collective

From Mah-Jong, to the introduction of Prussian war-games, through to the emergence of location-based play: maps and play share a long and diverse history. This monograph shows how mapping and playing unfold in the digital age, when the relations between these apparently separate tropes are increasingly woven together. Fluid networks of interaction have encouraged a proliferation of hybrid forms of mapping and playing and a rich plethora of contemporary case-studies, ranging from fieldwork, golf, activism and automotive navigation, to pervasive and desktop-based games evidences this trend. Examining these cases shows how mapping and playing can form productive synergies, but also encourages new ways of being, knowing and shaping our everyday lives. The chapters in this book explore how play can be more than just an object or practice, and instead focus on its potential as a method for understanding maps and spatiality. They show how playing and mapping can be liberating, dangerous, subversive and performative

Molecular Identification of African Trypanosome Stabilates from Livestock in Lamu County, Kenya

A study was conducted to characterize infectious trypanosomes in domestic animals within Lamu County, Kenya, using parasitological and molecular techniques. Fifteen trypanosome stabilates and 92 whole blood samples collected from parasitologically negative animals were randomly retrieved from the cryobank freezer at the Biotechnology Research Institute, (KALRO-BioRI), Kenya, and characterized. Human serum resistance associated (SRA) gene present in T. b. rhodesiense was used to differentiate T. brucei positive stabilates. Results showed that 10/15(67%) trypanosome stabilates and 13/92(14%) whole blood samples from cattle, donkeys and goats were positive using PCR. Positive T. congolense 5/23(22%) yielded a product size of 700bp using ITS1 primers. The Brucei group 7/23(30%) and T. vivax 11/23(48%) amplicons were 480bp and 250bp, respectively.  Identified trypanosome stabilates were T. b. brucei (7) T. vivax (2) and T. congolense Savannah (1). Whole blood PCR profiles revealed 13 isolates namely T. vivax (9) and T. congolense Savannah (4). Trypanosoma b. brucei, T. vivax and T. congolense Savannah were the etiological agents for AAT in donkeys. In contrast, T. vivax and T. congolense Savannah caused the disease in cattle, and T. b. brucei in goat within Lamu County. The study underscores the significance of molecular and parasitological methods during epidemiological monitoring and surveillance of disease. Keywords: Trypanosomes, livestock, PCR, Lamu County, Keny

Legal Rights and Issues Surrounding Conception, Pregnancy, and Birth

Advances in medicine are reported almost daily in the media. Medical researchers have developed and are continuing to develop new methods of creating, saving, and prolonging life. This Special Project examines the impact that rapidly advancing medical technology has on the law governing conception, pregnancy, and birth. Although medical techniques have advanced rapidly during the past decades, state and federal legislatures have responded in-adequately to the legal consequences of these new birth technologies. The resulting lag between technology and the law has forced courts to confront new situations that do not fit neatly into the statutory framework created to deal with past fact situations. For example, courts have applied statutes prohibiting child bartering to surrogate parenting cases and statutes prohibiting fetal experimentation to artificial insemination cases although it is clear that the legislators never considered such fact patterns when passing the statutes. A lag is inevitable because the law can only respond to, rather than predict, emerging medical developments. Nonetheless, legislators must respond promptly by confronting the new legal issues that result from new medical technologies. One impediment to prompt legislative response to the lag between medical technology and the law is the controversial nature of the legal problems posed. Abortion continues to be an extremely controversial issue thirteen years after the Supreme Court legalized it in the landmark decision Roe v. Wade. The Baby Doe issue of whether to force hospitals and parents of severely deformed newborns to provide medical care is another extremely controversial issue. Baby Doe has become highly politicized as the Reagan administration, Congress, right-to-life groups, disability groups, medical professionals, and other groups have taken stances. Surrogate parenting also has produced controversial situations. In one incident, a New York couple contracted with a California surrogate mother. When the surrogate mother breached the agreement, the couple brought suit. The court discovered that the couple consisted of a man and a transsexual, thus raising the issue of whether transsexuals or homosexuals should be allowed to adopt children by contracting with surrogate mothers

Ebola Hemorrhagic Fever Associated with Novel Virus Strain, Uganda, 2007–2008

Case-fatality rate is lower for this strain than for the other 3 Ebola species known to be pathogenic to humans